By Philip N Patsalos
This up to date 3rd version of a winning ebook is an outline of either pharmacokinetic and pharmacodynamic antiepileptic drug (AED) interactions, together with info of the significance and mechanism of interactions, and likewise of drug mixtures that aren't linked to interactions and for this reason may be coprescribed with out undue predicament. provided in alphabetical order and by way of drug category, drug interactions that take place among AEDs and in addition among AEDs and non-AEDs are defined in 3 sections: Drug interactions among AEDs; Drug interactions among AEDs and non-AED medicinal drugs: Interactions affecting AEDs; Drug interactions among AEDs and non-AED medicinal drugs: Interactions stricken by AEDs.
Antiepileptic Drug Interactions: A scientific consultant, third Edition with its transparent, concise and unambiguous content material will
allow physicians and allied future health execs to make extra rational offerings while AED polytherapy regimens are indicated. there's constantly a call and heading off hugely interacting medicines and selecting drug mixtures which are minimally interacting or don't have interaction may be the aim in treating sufferers with epilepsy. This ebook offers the entire invaluable details on the way to permit this objective to be accomplished and, if worthy, to help potent administration of AED interactions.
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Extra info for Antiepileptic Drug Interactions: A Clinical Guide
For example, interactions involving the active metabolite(s) of the coadministered drugs may not always be obvious if concurrent plasma level changes of the parent drug do not occur. Because it is not common practice to monitor plasma metabolite levels, if one is unaware of the interaction, blood level monitoring of the parent drug could be misleading. Such problematic interactions are associated with carbamazepine-10,11-epoxide, the pharmacologically active metabolite of carbamazepine. For example, during carbamazepine combination therapy with either valproate or quetiapine, patients can experience adverse effects as a result of an elevation of carbamazepine-10,11-epoxide levels resulting from an inhibition of epoxide hydrolase, without concurrent changes in plasma carbamazepine levels [28, 30].
Psychopharmacol Bull. 1990;26:181–4. 16. Huang CC, Wei IH. Unexpected interaction between quetiapine and valproate in patients with bipolar disorder. Gen Hosp Psychiatry. e1–2. 17. Junghan U, Albers M, Woggon B. Increased risk of haematological side-effects in psychiatric patients treated with clozapine and carbamazepine? Pharmacopsychiatry. 1993;26:262. 18. Bauer LA. Interference of oral phenytoin absorption by continuous nasogastric feedings. Neurology. 1982;32:570–2. Introduction xlix 19. Syversen GB, Morgan JP, Weintraub M, Myers GJ.
35. Garg SK, Kumar N, Bhargava VK, Prabhakar SK. Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy. Clin Pharmacol Ther. 1998;64:286–8. 36. Johannessen Landmark C, Patsalos PN. Methodologies used to identify and characterise interactions among antiepileptic drugs. Exp Rev Clin Pharmacol. 2012;5:281–92. 37. Johannessen SI, Bettino D, Berry DJ, Bialer M, Kramer G, Tomson T, Patsalos PN. Therapeutic drug monitoring of the newer antiepileptic drugs. Ther Drug Monit.
Antiepileptic Drug Interactions: A Clinical Guide by Philip N Patsalos